Summer school. Biomechanics: Trends in Modeling and Simulation

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Biomechanics: Trends in Modeling and Simulation

Graz University of Technology, Austria

September 8 - 12, 2014

Summer School coordinated by:

Gerhard A. Holzapfel, Graz University of Technology, Austria 
Ray W. Ogden, University of Glasgow, UK



The Summer School will present a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of biological tissue from the structural to the macroscopic level. The lecturers will discuss biomolecules, networks and cells as well as growth models appropriate for computational analysis. Applications include arteries, muscles, the heart, plants, neurons and tumours.

Cell migration, the mechanics of the whole cell and sub-cellular components will be discussed including smooth muscle cells and cardiac myocytes. This links with the discussion of growth, which builds on the constituents of soft tissue. Growth modeling includes applications to plants, bones, soft tissue, cancer and other human diseases.

Continuum mechanics underpins much of the modeling required in the biomechanics and mechanobiology of tissues. A summary of the key ingredients of continuum mechanics is therefore provided with particular emphasis on the nonlinear theory of elasticity, as a starting point for characterizing material properties. Models of the mechanical and other properties of individual biomolecules, networks of biomolecules and living cells will be examined. Also experimental techniques for determining the mechanical properties of biomolecules and cells will be presented. Modeling the interaction between growth, remodeling and the mechanics of biomolecules, cells and tissues will be discussed. Particular attention will be focused on modeling, finite element implementation and simulation of the mechanics, electromechanics, chemomechanics and electrophysiology of cells, artery walls, the heart and the cardiac cycle. This will include discussions of abdominal aortic aneurysms and heart valves. Adipose and epidermal tissues will also be discussed from both modeling and experimental perspectives.

Throughout the course the lecturers will point to future directions for research in the different areas of biomechanics and mechanobiology as well as coupled phenomena.


The Summer School is addressed to PhD students and postdoctoral researchers in biomedical engineering, (bio)physics, mechanical and civil engineering, applied mathematics, physiology and materials science and more senior scientists and engineers (including some from relevant industries) whose interests are in the area of biomechanics and mechanobiology.


8 Сен 2014 to 12 Сен 2014